Mini Episode: Bridging the Gap- Bupropion’s not your average wide QRS with Dr. Travis Olives

1. Rohr 2004- Gap junction blockade can cause a wide QRS 
2. Vink 2004 Connexin 43 is the most important protein for connexon formation and cardiac signal transmission
3. Callier 2012- Bupropion does not block sodium channels, and does exhibit similar effects on the cardiac action potential as known gap junction  
4. Burnham 2014 Bupropion has an IC50 for connexin 43 >50 uMol, larger than other drugs such as fluoextine and lamotrigine
5. Shaikh Quereshi 2014 Bupropion interferes with connexin43 production and localization in chicken cardiac myoctes at concentration >50 uMol

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