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Mini Episode: The Saga of the Cardiac Action Potential

  • Action potential
  • Sodium/Potassium ATPase pumps create more positively charged ions outside the cell than inside the cell, this creates a relative negative charge in the cell
  • Phase 4- Resting (~ -90 mv)
  • Phase 0- Sodium enters the cell (+10 mv) 
  • Phase 1- Potassium efflux from cell as now there is no negative charge holding it in (0 mv)
  •  Phase 2- Calcium channels open and allow calcium in, calcium triggers the ryandoine receptor and allows for calcium dependent calcium release from the sarcoplasmic reticulum occurs
  • Phase 3- Potassium continues to leave the cell  allowing return to -90 mv 

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About the Podcast

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The Poison Lab
Explore the world of poisoning with Clinical Toxicologist Ryan Feldman and Cohost Toxo, dive into the history, science, and life-saving care of poisoning. Survivor stories, expert insights, and deep dives—every poison has a story to tell!

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About your host

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Ryan Feldman

Dr. Ryan Feldman PharmD, DABAT is the chief scientist at The Poison Lab. He works as a Clinical Toxicologist, Emergency Medicine Pharmacist, and Clinical Assistant Professor of Pharmacy and Emergency medicine.