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Mini Episode: Bridging the Gap- Bupropion's not your average wide QRS with Dr. Travis Olives

  1. Rohr 2004- Gap junction blockade can cause a wide QRS 
  2. Vink 2004 Connexin 43 is the most important protein for connexon formation and cardiac signal transmission
  3. Callier 2012- Bupropion does not block sodium channels, and does exhibit similar effects on the cardiac action potential as known gap junction  
  4. Burnham 2014 Bupropion has an IC50 for connexin 43 >50 uMol, larger than other drugs such as fluoextine and lamotrigine
  5. Shaikh Quereshi 2014 Bupropion interferes with connexin43 production and localization in chicken cardiac myoctes at concentration >50 uMol

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About the Podcast

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The Poison Lab
Explore the world of poisoning with Clinical Toxicologist Ryan Feldman and Cohost Toxo, dive into the history, science, and life-saving care of poisoning. Survivor stories, expert insights, and deep dives—every poison has a story to tell!

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Ryan Feldman

Dr. Ryan Feldman PharmD, DABAT is the chief scientist at The Poison Lab. He works as a Clinical Toxicologist, Emergency Medicine Pharmacist, and Clinical Assistant Professor of Pharmacy and Emergency medicine.