Captivate Podcasts

What substance could cause these symptoms? Send your guesses to Toxtalk1@gmail.com to participate in episode 10! Support the showReview the show where ever your listeningGet Messages from Toxo (Join the Newsletter!)Join as a supporting memberAd free episodesBonus content and early accessDiscounts and give aways on GOTA PICCEM Mushroom card gameThe GOTTA PICCEM Poisonous Mushroom Game!The […]

In this episode of toxicologist vs the internet Ryan Is joined by special guest Dr. Justin Corcoran, MD an emergency medicine physician and medical toxicologist. They take turns answering questions from reddit.com/r/askdrugs (the internet, really, really needs a toxicologist) and challenge each others toxic sleuthing by presenting cases of poisoning and allowing the other to

Ryan and Toxo dive in to Delta 8 THC, a new (maybe?) legal drug sweeping the U.S. Delta-8 THC: Key Resources and Studies New York Times Coverage Comprehensive article on Delta-8 THC, its growing popularity, and concerns: https://www.nytimes.com/2021/02/27/health/marijuana-hemp-delta-8-thc.html Studies of Delta-8 THC in Humans Systematic Review: Summarizes findings from a single key study on Delta-8

Case from the show https://pubmed.ncbi.nlm.nih.gov/22163140/ Mithradates https://www.wemjournal.org/article/S1080-6032(11)00043-3/pdf Case series on mad honey effects https://pubmed.ncbi.nlm.nih.gov/20575670/ Blog post on sodium channel openers https://emcrit.org/toxhound/ff-plant-sodium-channel-openers/ Support the showReview the show where ever your listeningGet Messages from Toxo (Join the Newsletter!)Join as a supporting memberAd free episodesBonus content and early accessDiscounts and give aways on GOTA PICCEM Mushroom card gameThe

In this second rendition of toxicologist vs the internet Ryan Is joined by special guest Dr. Jillian Theobald, MD, PHD an emergency medicine physician and medical toxicologist. They take turns answering questions from reddit.com/r/askdrugs (the internet, really, really needs a toxicologist) and challenge each others toxic sleuthing by presenting cases of poisoning and allowing the

Quick Review: Chloroquine and Hydroxychloroquine Toxicity Toxic Dose Chloroquine: >5 g is associated with severe toxicity (though toxicity can occur at lower doses). Hydroxychloroquine (HCQ): Toxic dose is less well-defined. Clinical Effects Seizures: Due to sodium channel blockade. Arrhythmias: Resulting from sodium channel blockade. Hypotension: Caused by alpha-adrenergic blockade. Hypokalemia: Often a notable feature. Management

In this episode Ryan and Toxo discuss some potential toxic spices and break down the toxicity and treatment of a once well known medicine Cinchona Bark, Quinine, and Associated Toxicities Historical Perspective Use of Cinchona Bark Powder for Malaria: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973170/ Evolutionary Pressure of Malaria on Sickle Cell Traits: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499995/ Cinchonism Definition: Classic toxicities caused by

In this episode Ryan Is joined by a special guest Dr. Matthew Stanton PharmD, BCPS, DABAT, an emergency medicine pharmacist and clinical toxicologist. Ryan and Matt take turns answering questions from reddit.com/r/askdrugs (the internet, really, really needs a toxicologist) and finally they challenge each others toxic sleuthing by presenting some cases of poisoning and allowing

Action potential Sodium/Potassium ATPase pumps create more positively charged ions outside the cell than inside the cell, this creates a relative negative charge in the cell Phase 4- Resting (~ -90 mv) Phase 0- Sodium enters the cell (+10 mv)  Phase 1- Potassium efflux from cell as now there is no negative charge holding it

Great review of potential torsades mechanisms based off experimental data- https://www.sciencedirect.com/science/article/pii/S1880427611800050 Support the showReview the show where ever your listeningGet Messages from Toxo (Join the Newsletter!)Join as a supporting memberAd free episodesBonus content and early accessDiscounts and give aways on GOTA PICCEM Mushroom card gameThe GOTTA PICCEM Poisonous Mushroom Game!The Poisonus Fungus Amongus Children’s Book!Full